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The Drug-Free Solution for Migraine

and Cluster Headache

Treats and prevents migraine and cluster headache without pills, injections or drug like side effects.

GammaCore SapphireTM is the first and only FDA cleared non-invasive device to treat and prevent multiple types of headache pain via the vagus nerve. It’s small, handheld and portable for quick and easy treatments whenever and wherever needed.

For acute use:

Treat right away and with a few 2-minute treatments, you could see fast acting, long-lasting pain relief.

To prevent future headache pain:

Simply treat 3 times a day for more headache free days, so you can live life with less disruption.


Safe and well tolerated

Patients treated with gammaCore did not experience any serious treatment-related side effects. Most side effects are mild, occur during the use of the device, and go away quickly after each treatment.

The most common side effects include discomfort and redness at the application site as well as dizziness. A tingling feeling where the device is applied is normal, but it should not cause major discomfort.


How gammaCore works

gammaCore (nVNS) activates the vagus nerve with patented, gentle electrical stimulation.

  • The vagus nerve is an important highway of communication between your brain and many parts of the body

  • The vagus nerve plays an important role in regulating pain


Non-invasive vagus nerve stimulation with gammaCore is believed to help block the pain signals that cause migraines and cluster attacks.


  • Unlike traditional vagus nerve stimulation therapies, gammaCore stimulates the nerve non-invasively through the skin without the need for surgery

  • Avoids many drug-like side effects and inconveniences associated with injectable, inhaled, or pill-based medicines

How to use gammaCore Sapphire

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